Key result
The LIPG gene -384A/C polymorphism (allele C) was significantly associated with an increased risk of coronary artery disease in Han Chinese individuals (OR 1.437; 95% CI 1.078-1.915; p=0.013).
Why the study?
Are the LIPG gene SNPs 584C/T and -384A/C associated with coronary artery disease in Han Chinese people?
Case-Control (n=654)
Are the LIPG gene SNPs 584C/T and -384A/C associated with coronary artery disease in Han Chinese people?
Odds Ratio: 1.437 (95% CI 1.078–1.915)
Absolute Event Rate: 20.2% vs 15%
p-value: p=0.013
The SNP -384A/C in the endothelial lipase gene (LIPG) is associated with an increased risk of coronary artery disease in the Han Chinese population.
Supports LIPG -384A/C as CAD risk variant in Han Chinese; hypothesis-generating and requires replication before clinical use.
OBJECTIVES: The endothelial lipase gene (LIPG) is one of the important genes in the metabolism of high-density lipoprotein cholesterol (HDL-C) and may be involved in the pathogenesis of coronary artery disease (CAD). MATERIALS AND METHODS: To investigate the relationship between the common single nucleotide polymorphisms (SNPs) 584C/T (rs2000813) and -384A/C (rs3813082) in the LIPG gene and CAD, allele and genotype frequencies of the two SNPs were analysed in 287 Chinese patients with CAD and 367 controls by the high-resolution melting curve (HRM) method. RESULTS: For 584C/T, no significant difference in polymorphic distribution was observed between patients and controls. However, the frequencies of allele C (20.2% vs 15%, p=0.013, OR=1.437, 95% CI 1.078 to 1.915) at -384A/C were significantly increased in patients compared with controls. Haplotype analysis also showed that haplotype CT (12.37% vs 8.72%, p=0.035, OR=1.478, 95% CI 1.034 to 2.112) was significantly higher in patients compared with controls. CONCLUSIONS: These results suggested that the SNP -384A/C in the LIPG gene may be associated with risk for CAD and the LIPG gene may play a role in CAD in the Han Chinese.
No takes yet. Share an insight, caveat, or question.
Xie et al. (2015) conducted a case-control in Coronary artery disease (n=654). LIPG gene -384A/C polymorphism (allele C) vs. Controls (without CAD) was evaluated on Frequency of allele C at -384A/C (OR 1.437, 95% CI 1.078 to 1.915, p=0.013). The LIPG gene -384A/C polymorphism (allele C) was significantly associated with an increased risk of coronary artery disease in Han Chinese individuals (OR 1.437; 95% CI 1.078-1.915; p=0.013).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: