Key result
The minor allele of rs632793 in the BNP gene region was independently associated with higher serum NT-proBNP levels (β 0.16) and lower prevalent cardiovascular disease.
Why the study?
Little is known about the heritability and genetic variants associated with the cardiovascular disease biomarker NT-proBNP.
Observational (n=4,331)
Yes
Effect estimate: β 0.16
p-value: p=<0.001
In a family-based study of subjects with exceptional longevity, NT-proBNP was found to be heritable, and specific allelic variants in the BNP gene region were associated with NT-proBNP levels and prevalent CVD.
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Supports NT-proBNP heritability in longevity families; extends genetic associations but leaves causal roles open in observational data.
Yang et al. (2021) conducted an observational in Prevalent cardiovascular disease (n=4,331). Minor alleles of SNPs in the NPPA/NPPB region (e.g., rs632793) vs. Major allele homozygotes was evaluated on Log-transformed serum NT-proBNP levels (β 0.16, p=<0.001). The minor allele of rs632793 in the BNP gene region was independently associated with higher serum NT-proBNP levels (β 0.16) and lower prevalent cardiovascular disease.
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