Key result
Deficiencies in the Pbx gene family and Meis1 in mice produce a full spectrum of cardiac defects involving the outflow tract, demonstrating multigenetic origins of congenital heart anomalies.
Authors
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May inform genetic studies of congenital heart disease; leaves open validation of Pbx/Meis1 variants in patients.
Stankunas et al. (2008) studied Congenital heart diseases. Pbx/Meis gene deficiencies was evaluated on Phenotypic presentation of congenital heart diseases. Deficiencies in the Pbx gene family and Meis1 in mice produce a full spectrum of cardiac defects involving the outflow tract, demonstrating multigenetic origins of congenital heart anomalies.
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