Key result
The MICROS population-based survey of 1,175 adults in three South Tyrolean microisolates demonstrated significant familial clustering for multiple complex traits and substantial power to detect genetic linkage.
Population
1,175 adult volunteers from three small, isolated villages in South Tyrol, Italy, characterized by old…
Design
Cohort
Authors
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Supports isolate cohorts for complex trait linkage; leaves open generalizability and clinical translation pending replication.
Cross-Sectional (n=1,175)
Yes
The MICROS study establishes a well-characterized genetic isolate cohort in the Italian Alps with extensive genealogical records, providing a powerful resource for future linkage and association studies of complex diseases.
Pattaro et al. (2007) conducted a cross-sectional in Genetic epidemiology of complex diseases (n=1,175). Living in population microisolates was evaluated on Probability of familial clustering and power to detect linkage for quantitative trait loci. The MICROS population-based survey of 1,175 adults in three South Tyrolean microisolates demonstrated significant familial clustering for multiple complex traits and substantial power to detect genetic linkage.
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