Key result
The PopGen project established a large-scale genetic epidemiological cohort in northern Germany to analyze complex genotype-phenotype relationships across various diseases.
Observational
Yes
The PopGen project provides a large-scale genetic epidemiological resource for analyzing complex genotype-phenotype relationships in northern Germany.
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Expands regional resources for genotype-phenotype research; leaves open generalizability and clinical translation.
OBJECTIVE: Patient samples used for mapping complex human disease genes are unlikely to be representative of the phenotype spectrum of the respective population as a whole. On the other hand, most ongoing prospective studies are probably too small for evaluating polygenic disease markers. DESIGN: Precise estimates of population-specific genotypic risks can be obtained efficiently through the complete ascertainment of patients in a geographically confined area. The PopGen project uses the most northern part of Germany as a target region for such a pursuit. RESULTS: PopGen currently pursues recruitment, sampling and processing activities in close collaboration with a multitude of clinical partners, covering cardiovascular, neuropsychiatric and environmental diseases. CONCLUSION: PopGen has successfully established itself as a large-scale genetic epidemiological project of international recognition.
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Krawczak et al. (2006) conducted an observational in Complex human diseases (cardiovascular, neuropsychiatric, and environmental). Population-based recruitment (PopGen project) was evaluated. The PopGen project established a large-scale genetic epidemiological cohort in northern Germany to analyze complex genotype-phenotype relationships across various diseases.
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