Key result
Increasing age was associated with declines in mean cerebral blood flow velocity (-0.5 cm/s per year) and CO2 reactivity, while men had lower velocities than women (mean difference 2.5 cm/s).
Population
1,720 elderly participants of a population-based study (The Rotterdam Study)
Design
Cross-sectional
Authors
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Normative cerebral hemodynamic data by age and sex should inform reference ranges; leaves open prognostic relevance and need for longitudinal validation.
Cross-Sectional (n=1,720)
Cerebral blood flow velocities and CO2 reactivity decline with age and differ by sex, providing normative data for physiological aging of cerebral hemodynamics.
Bakker et al. (2004) conducted a cross-sectional in Ageing (n=1,720). Ageing and male sex vs. Younger age and female sex was evaluated on Cerebral haemodynamic parameters (blood flow velocities, CO2 reactivity, pulsatility index). Increasing age was associated with declines in mean cerebral blood flow velocity (-0.5 cm/s per year) and CO2 reactivity, while men had lower velocities than women (mean difference 2.5 cm/s).
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