Key result
Placement of sirolimus-eluting stents was associated with the development of severe, multivessel coronary vasospasm a few months post-procedure in two patients.
Case Report (n=2)
Sirolimus-eluting stents may pose a risk of delayed and widespread postangioplasty coronary spasm due to biocellular interference with endothelial equilibrium.
May warrant vigilance for delayed vasospasm after sirolimus-eluting stents; hypothesis-generating case report requiring confirmation.
We describe two cases of severe, multivessel coronary vasospasm that occurred a few months after placement of sirolimus-eluting stents in patients with severe coronary disease, and involved segments not significantly atheromatous and not previously treated. The literature suggests that biocellular interference with the endothelial equilibrium on the part of drugs eluted from a stent poses a serious risk of tardive and widespread postangioplasty coronary spasm in comparison with the use of a bare-metal stent.
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Tomassini et al. (2009) conducted a case report in Severe coronary disease (n=2). Sirolimus-eluting stents was evaluated on Severe, multivessel coronary vasospasm. Placement of sirolimus-eluting stents was associated with the development of severe, multivessel coronary vasospasm a few months post-procedure in two patients.
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