Combustion-derived nanoparticulate induces the adverse vascular effects of diesel exhaust inhalation
Key result
Diesel exhaust inhalation increases systolic blood pressure by ~12 mmHg and impairs vasodilation vs filtered air.
- P<0.05
- n=16
Why the study?
The individual pollutants responsible for the adverse cardiovascular effects of road traffic and air pollution have not been established.
Does inhalation of diesel exhaust components impair vascular function in healthy volunteers?
Population
16 healthy volunteers
Comparison
Dilute diesel exhaust vs pure carbon nanoparticulate vs filtered diesel exhaust vs filtered air
Design
Randomized double blind cross-over study
Authors
Discussion
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Member takes
Implication
Supports reducing diesel exhaust exposure in at-risk settings; extends RCT evidence on combustion-specific vascular impairment in humans.
Study Design
Type
RCT (n=16)
Blinding
double blind
Randomization
randomized cross-over
Structured PICO
Does inhalation of diesel exhaust components impair vascular function in healthy volunteers?
P
Population
16 healthy volunteers exposed to various diesel exhaust components and filtered air in a randomized cross-over study.
I
Intervention
Inhalation of dilute diesel exhaust, pure carbon nanoparticulate, or filtered diesel exhaust (in vivo); exposure to diesel exhaust particulate or pure carbon nanoparticulate (in vitro)
C
Comparator
Filtered air (in vivo); vehicle (in vitro)
O
Outcome
Forearm blood flow during intra-brachial bradykinin, acetylcholine, sodium nitroprusside, and verapamil infusions; systolic blood pressure (in vivo). Vasorelaxation (in vitro).surrogate
Main Result
Absolute Event Rate: 145% vs 133%
p-value: p=< 0.05
Combustion-derived nanoparticulate from diesel exhaust mediates adverse vascular effects, including increased blood pressure and impaired vasodilation, providing a rationale for reducing traffic-derived particulate emissions.
Cite This Study
Mills et al. (2011) conducted an RCT in healthy (n=16). dilute diesel exhaust vs. filtered air was evaluated on systolic blood pressure (p=< 0.05). Inhalation of dilute diesel exhaust increased systolic blood pressure (145 vs 133 mmHg, P<0.05) and attenuated vasodilatation compared with filtered air.