Female breast cancer patients who did not receive chemotherapy or radiotherapy had a significantly higher risk of cardiovascular death compared to the general population (SMR 2.196).
Cohort (n=131,306)
Yes
Does tumor resection reduce cardiovascular death in female breast cancer patients who do not receive chemotherapy or radiotherapy?
Female breast cancer patients not exposed to cardiotoxic therapies still face an elevated risk of cardiovascular death, though tumor resection is associated with a reduced risk, suggesting a need for broader cardiovascular monitoring in cardio-oncology.
Effect estimate: SMR 2.196 (95% CI 2.148-2.245)
p-value: p=<0.001
Background Cardiovascular death (CVD) in breast cancer patients without chemotherapy (CT) or (and) radiotherapy (RT) has not been studied yet. This study evaluates the correlation between breast cancer and CVD risk independent of chemotherapy or (and) radiotherapy. Methods Data of female breast cancer patients without receiving CT or RT were retrieved from the Surveillance, Epidemiology, and End Result (SEER) database (2004–2015). Data were divided into two cohorts: tumor resection cohort and no resection cohort. The CVD risk in patients was expressed as standardized mortality ratios (SMRs). A 1:1 propensity score matching (PSM) was applied to balance inter-group bias, and competing risk regressions were utilized to evaluate the impact of tumor resection on CVD. Results The CVD risk was significantly higher (SMR = 2.196, 95% CI: 2.148–2.245, P 0.001) in breast cancer patients who did not receive CT or RT compared to the general population. Breast cancer patients without tumor resection showed higher CVD risk than patients who underwent tumour resection (tumor resection SMR = 2.031, 95% CI: 1.983–2.079, P 0.001; no resection SMR = 5.425, 95% CI: 5.087–5.781, P 0.001). After PSM, the CVD risk among patients without tumor resection indicated an increase of 1.165-fold compared to patients with tumor resection (HR=1.165, 95% CI: 1.039–1.306, P =0.009). Conclusions Female breast cancer patients are at higher risk of CVD despite unexposure to cardio-toxic CT or RT. However, female breast cancer patients subjected to tumor resection have decreased CVD risk. These results indicated that monitoring female breast cancer patients not receiving RT or CT might serve as a preventative measure against CVD.
Guan et al. (Thu,) conducted a cohort in Breast cancer without chemotherapy or radiotherapy (n=131,306). Breast cancer without chemotherapy or radiotherapy vs. General population was evaluated on Cardiovascular death (SMR 2.196, 95% CI 2.148-2.245, p=<0.001). Female breast cancer patients who did not receive chemotherapy or radiotherapy had a significantly higher risk of cardiovascular death compared to the general population (SMR 2.196).