Key result
Supervised training reverses EOV in a patient with multiple sclerosis and no cardiac abnormalities.
Why the study?
Exercise oscillatory ventilation mainly occurs in heart failure and is tied to poor prognosis, with limited information available regarding its occurrence in other populations.
Does an 11-week supervised exercise training program reverse exercise oscillatory ventilation in a deconditioned patient with multiple sclerosis and no cardiac failure?
Case Report (n=1)
No
Does an 11-week supervised exercise training program reverse exercise oscillatory ventilation in a deconditioned patient with multiple sclerosis and no cardiac failure?
Exercise oscillatory ventilation, typically a poor prognostic marker in heart failure, can occur in deconditioned patients without cardiac abnormalities and may be reversed with exercise training.
Should not yet change practice for EOV in MS; hypothesis-generating for reversal by exercise outside cardiac failure.
Exercise oscillatory ventilation (EOV), which occurs mainly in heart failure patients, is associated with poor prognosis. There is limited information on EOV in other populations. Here we present a case study of a young woman with relapsing-remitting multiple sclerosis who was referred for cardiopulmonary exercise testing (CPET). There were no indications of cardiac problems during the medical screening. However, during CPET, EOV was observed. Additional diagnostic tests showed no cardiovascular anomalies. After a training period, CPET was repeated and EOV had disappeared, showing that EOV can occur during exercise in patients without cardiac abnormalities and that improving the general fitness may reverse this breathing pattern.
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Musch et al. (2025) conducted a case report in Relapsing-remitting Multiple Sclerosis with Exercise Oscillatory Ventilation (n=1). Supervised outpatient training program (sprint interval and strength training) vs. Baseline (pre-training) was evaluated on Presence of Exercise Oscillatory Ventilation (EOV) during cardiopulmonary exercise testing. An 11-week supervised training program reversed exercise oscillatory ventilation in a 30-year-old woman with relapsing-remitting multiple sclerosis and no cardiac abnormalities.
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