Key result
Loss of perivascular adipose tissue due to PPAR-γ deletion impaired intravascular thermoregulation and exacerbated atherosclerosis by preventing cold-induced lipid clearance and endothelial protection.
Why the study?
Does cold exposure prevent atherosclerosis and improve endothelial function in mice with intact perivascular adipose tissue?
Does cold exposure prevent atherosclerosis and improve endothelial function in mice with intact perivascular adipose tissue?
Perivascular adipose tissue possesses thermogenic properties similar to brown adipose tissue that protect against endothelial dysfunction and atherosclerosis during cold acclimation.
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PVAT thermogenesis may mediate cold-induced vascular protection in mice; hypothesis-generating, with human translation untested.
Chang et al. (2012) studied Atherosclerosis. Peroxisome proliferator-activated receptor-γ deletion in smooth muscle cells (SMPG KO) and cold exposure vs. Mice with intact PVAT was evaluated on Atherosclerosis and endothelial function. Loss of perivascular adipose tissue due to PPAR-γ deletion impaired intravascular thermoregulation and exacerbated atherosclerosis by preventing cold-induced lipid clearance and endothelial protection.
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