Anorganische Amyloidinhibitoren: Vier Arten von Polyoxometallaten (POMs) erwiesen sich als effiziente Inhibitoren der Amyloidbildung durch Amyloid-β-Peptide (Aβ; siehe Bild: anders als das obere POM (rot) inhibierte das untere (dunkelgrün) die Amyloidbildung). Die Inhibitionsselektivität der POMs beruht auf größenspezifischen elektrostatischen Wechselwirkungen zwischen den POMs und Aβ über die Bindung an die positiv geladene His13–Lys16-Clusterregion von Aβ. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Geng et al. (2011) studied this question.
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