Key result
Adiponectin and neuregulin 4 are linked to atherosclerosis protection while leptin and resistin exacerbate progression.
Why the study?
Adipokines are implicated in atherosclerosis risk, progression, and regression, but their complex roles and the specific function of newly discovered adipokines like asprosin remain incompletely understood.
Adipokines play complex, multifaceted roles in atherosclerosis, acting as both protective and deteriorating factors, which may serve as future therapeutic targets to halt disease progression.
Answers are grounded in this paper and cite their sources.
Adipokines may offer future therapeutic targets in atherosclerosis; leaves open validation in prospective trials.
Adipokines are biologically active factors secreted by adipose tissue that act on local and distant tissues through autocrine, paracrine, and endocrine mechanisms. However, adipokines are believed to be involved in an increased risk of atherosclerosis. Classical adipokines include leptin, adiponectin, and ceramide, while newly identified adipokines include visceral adipose tissue-derived serpin, omentin, and asprosin. New evidence suggests that adipokines can play an essential role in atherosclerosis progression and regression. Here, we summarize the complex roles of various adipokines in atherosclerosis lesions. Representative protective adipokines include adiponectin and neuregulin 4; deteriorating adipokines include leptin, resistin, thrombospondin-1, and C1q/tumor necrosis factor-related protein 5; and adipokines with dual protective and deteriorating effects include C1q/tumor necrosis factor-related protein 1 and C1q/tumor necrosis factor-related protein 3; and adipose tissue-derived bioactive materials include sphingosine-1-phosphate, ceramide, and adipose tissue-derived exosomes. However, the role of a newly discovered adipokine, asprosin, in atherosclerosis remains unclear. This article reviews progress in the research on the effects of adipokines in atherosclerosis and how they may be regulated to halt its progression.
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Luo et al. (2023) conducted a review in Atherosclerosis. Adipokines was evaluated. Adipokines play complex regulatory roles in atherosclerosis, with adiponectin and neuregulin 4 offering protective effects, while leptin and resistin exacerbate disease progression.
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