The (18)O-induced isotope shifts in (13)C NMR spectra of 1:1 complexes of Cl(2)CHC(18)O(2)H with a series of substituted pyridines in CD(2)Cl(2) at low temperature reach a maximum when the acidities of the hydrogen-bond donors are matched, consistent with a mixture of tautomers, and with no drop that would indicate a single-well H-bond.
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Perrin et al. (2009) studied this question.
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