In the United States, these double-edged drugs cause as many as 20,000 deaths a year. To blunt their harmful effects, two promising strategies are being pursued: concurrent administration of prostaglandin analogues to support gastric homeostasis, and the development, or identification among existing NSAIDs, of an agent that targets inflammatory prostaglandins while sparing the homeostatic ones.
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M. Michael Wolfe (1996) studied this question.