⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

December 7, 2016OncoImmunologyOpen Access

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

Cheng Sun Jing Xu Qiang Huang Mei Huang Hao Wen Chuanshan Zhang Jinyu Wang Jiaxi Song Meijuan Zheng Haoyu Sun Haiming Wei Weihua Xiao Rui Sun Zhigang Tian

View Full Paper

Ask AI

Bookmark

Share

Abstract

: These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Sun et al. (2016) studied this question.

synapsesocial.com/papers/6a210676f75d077b3816d7aa https://doi.org/10.1080/2162402x.2016.1264562

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapyClinical Trial · 2015 · 213 citations
2Chemokine-driven lymphocyte infiltration: an early intratumoural event determining long-term survival in resectable hepatocellular carcinomaPrognostic Study · 2011 · 359 citations
3Monocyte/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48/2B4 interactionsOriginal Research · 2012 · 266 citations
4Myeloid derived suppressor cells inhibit natural killer cells in patients with hepatocellular carcinoma via the NKp30 receptor #Original Research · 2009 · 643 citations
5Liver natural killer cells: subsets and roles in liver immunityReview · 2015 · 183 citations

Negative Regulation of NK Cell Activities by Inhibitory Receptor CD94/NKG2A Leads to Altered NK Cell-Induced Modulation of Dendritic Cell Functions in Chronic Hepatitis C Virus Infection2004
TGF-β1 Down-Regulation of NKG2D/DAP10 and 2B4/SAP Expression on Human NK Cells Contributes to HBV Persistence2012
B7-H1–expressing antigen-presenting cells mediate polarization of protumorigenic Th22 subsets2014
Mast cell phenotypic remodeling toward a PD-1-positive, Chymase-negative phenotype is associated with metastatic melanoma and poor survivalOncoImmunology · 2026
Glioblastoma immune landscape remodeling following treatment with CD70-targeted CAR-T cellsOncoImmunology · 2026

More from OncoImmunology