Key result
Being a homozygous carrier of the major allele (GG) of rs1131820 in KCNN3 was associated with lone atrial fibrillation compared to the minor allele (AA) (OR 2.85; 95% CI 1.13-7.18; P=0.026).
Why the study?
Are mutations or variations in the KCNN3 gene associated with early-onset lone atrial fibrillation?
Population
209 early-onset lone atrial fibrillation patients and 208 healthy blood donors with normal ECGs and without…
Comparison
Genetic screening of KCNN3 vs Healthy blood donors with normal ECGs and…
Design
Case-control
Authors
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rs1131820 GG associates with lone AF; hypothesis-generating for KCNN3 variants in early-onset disease.
Case-Control (n=417)
Are mutations or variations in the KCNN3 gene associated with early-onset lone atrial fibrillation?
Odds Ratio: 2.85 (95% CI 1.13–7.18)
p-value: p=0.026
While no coding mutations were found in KCNN3, the synonymous SNP rs1131820 is significantly associated with early-onset lone atrial fibrillation in a Danish cohort.
Olesen et al. (2011) conducted a case-control in Early-onset lone atrial fibrillation (n=417). Homozygous carrier of the major allele (GG) of rs1131820 in KCNN3 vs. Homozygous carrier of the minor allele (AA) of rs1131820 was evaluated on Lone atrial fibrillation (OR 2.85, 95% CI 1.13-7.18, p=0.026). Being a homozygous carrier of the major allele (GG) of rs1131820 in KCNN3 was associated with lone atrial fibrillation compared to the minor allele (AA) (OR 2.85; 95% CI 1.13-7.18; P=0.026).
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