Key result
A pulsatile sixth-order lumped parameter model of the cardiovascular system successfully achieved phasic coronary flow and emulated realistic coronary microvascular resistance under stenotic conditions.
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A lumped parameter computational model can simulate realistic coronary microvascular resistance and phasic flow under varying degrees of coronary stenosis.
Coronary flow control mechanisms maintain the average coronary blood flow (CBF) at 4% of the cardiac output (CO) in normal adults, with no prior diagnosis of coronary artery disease (CAD), under resting conditions. This paper explores a pulsatile sixth order lumped parameter (LP) model of the cardiovascular system (CVS) which utilizes the average CBF approximated from CO along with arterial blood pressure (ABP) waveform to estimate the coronary microvascular resistance using non-linear least square optimization technique. The CVS model includes a third order model of the coronary vascular bed and is shown to achieve phasic coronary flow. The coronary epicardial resistance is varied to emulate different degrees of stenosis and achieve realistic behavior of coronary microvascular resistance under these conditions.
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Sahoo et al. (2022) studied Coronary artery disease (simulated stenotic conditions). Pulsatile sixth order lumped parameter model was evaluated on Estimation of coronary microvascular resistance and achievement of phasic coronary flow. A pulsatile sixth-order lumped parameter model of the cardiovascular system successfully achieved phasic coronary flow and emulated realistic coronary microvascular resistance under stenotic conditions.
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