Key result
Long-term smoking significantly increased the transcapillary escape rate of albumin to an average of 12.3% per hour, twice as high as in young smokers and non-smokers.
Why the study?
Does long-term smoking increase the transcapillary escape rate of albumin in healthy male subjects?
Population
11 young and 10 healthy, elderly male subjects, approximately half of whom were chronic cigarette smokers
Comparison
Long-term smoking (chronic cigarette smoking) vs Young smokers, young non-smokers, and elderly…
Design
Cross-sectional
Authors
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Smoking may increase capillary permeability in healthy men; hypothesis-generating for vascular damage mechanisms, needs prospective confirmation.
Cross-Sectional (n=21)
Does long-term smoking increase the transcapillary escape rate of albumin in healthy male subjects?
Long-term smoking significantly increases capillary permeability to albumin, highlighting a potential mechanism for smoking-induced vascular damage.
Jensen et al. (1992) conducted a cross-sectional in Healthy (n=21). Long-term smoking vs. Young smokers and young and elderly non-smokers was evaluated on Transcapillary escape rate of albumin (percentage of decrease in specific activity of plasma albumin per hour). Long-term smoking significantly increased the transcapillary escape rate of albumin to an average of 12.3% per hour, twice as high as in young smokers and non-smokers.
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