Key result
Maternal pregestational diabetes shows no significant association with altered fetal cardiac contractility on ultrasound.
Why the study?
This study aimed to evaluate cardiac contractility in fetuses from pregestational diabetes mellitus pregnancies using three-dimensional ultrasound with spatiotemporal image correlation in rendering mode.
Does maternal pregestational diabetes alter fetal cardiac contractility as measured by three-dimensional ultrasound using spatiotemporal image correlation in rendering mode?
Cross-Sectional (n=68)
No
Does maternal pregestational diabetes alter fetal cardiac contractility as measured by three-dimensional ultrasound using spatiotemporal image correlation in rendering mode?
Absolute Event Rate: 1.21% vs 1.47%
p-value: p=0.293
Fetal cardiac contractility assessed by 3D ultrasound with STIC in rendering mode showed no significant differences between well-controlled pregestational diabetic and nondiabetic pregnancies.
No change to fetal surveillance indicated; leaves open effects of glycemic control or long-term cardiac outcomes in pregestational diabetes.
OBJECTIVE: This study aimed to evaluate cardiac contractility in fetuses from pregestational diabetes mellitus pregnancies by three-dimensional ultrasound using spatiotemporal image correlation in rendering mode. METHODS: A retrospective cross-sectional study was performed on 40 fetuses from nondiabetic pregnancies and 28 pregestational diabetic pregnancies between 20 and 33 weeks and 6 days. Cardiac contractility was assessed by measuring the ventricular myocardial area in diastole subtracted from the ventricular myocardial area in systole. RESULTS: Pregestational diabetic pregnancies had a lower maternal age than nondiabetic pregnancies (26.7 vs. 39.9 years, p=0.019). Cardiac contractility in fetuses from diabetic and nondiabetic pregnancies was similar (p=0.293). A moderately positive and significant correlation was observed between gestational age and cardiac contractility (r=0.46, p=0.0004). A 1-week increase in gestational age was responsible for a 0.1386 cm2 increase in cardiac contractility. CONCLUSION: Cardiac contractility as evaluated by three-dimensional ultrasound using spatiotemporal image correlation in rendering mode showed no significant differences across fetuses with and without pregestational diabetes.
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Caetano et al. (2024) conducted a cross-sectional in Fetal exposure to maternal pregestational diabetes mellitus (n=68). Pregestational diabetes mellitus vs. Nondiabetic pregnancy was evaluated on Cardiac contractility (difference in ventricular myocardial area between diastole and systole in cm2) (p=0.293). Fetal cardiac contractility evaluated by 3D ultrasound showed no significant differences between fetuses from mothers with pregestational diabetes and nondiabetic mothers (1.21 vs 1.47 cm2, p=0.293).
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