Key result
Longitudinal stretch induces markedly greater acute transcriptional responses than transverse stretch in mouse ventricular myocytes.
Neonatal mouse ventricular myocytes demonstrate higher sensitivity to longitudinal loading than transverse loading, leading to greater acute transcriptional responses.
Orientation-dependent stretch sensitivity in neonatal myocytes merits attention in mechanotransduction studies; leaves open applicability to adult human hearts.
Anisotropic stretch applied to micropatterned neonatal mouse ventricular myocytes induced markedly greater acute transcriptional responses when the major axis of stretch was parallel to the myofilament axis than when it was transverse. Analysis with a novel quantitative network model of mechanoregulated cardiomyocyte gene expression suggests that this difference is explained by higher cell sensitivity to longitudinal loading than transverse loading than by the activation of differential signaling pathways.
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Cao et al. (2023) studied this question. Longitudinal stretch vs. Transverse stretch was evaluated on Transcriptional responses. Longitudinal stretch applied to mouse neonatal ventricular myocytes induced markedly greater acute transcriptional responses compared to transverse stretch.
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