Why the study?
Conflicting results exist and there is no uniform agreement regarding sex differences in survival and prognosis after out-of-hospital cardiac arrest.
Does female sex reduce survival and favorable neurological outcomes in patients with out-of-hospital cardiac arrest compared to male sex?
Population
1,268,664 patients across 33 studies
Comparison
Females vs males
Design
Meta-analysis
Key result
Female sex was associated with a significantly lower chance of overall survival to hospital discharge after out-of-hospital cardiac arrest compared with male sex (OR 0.73).
Authors
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Female sex associated with lower OHCA survival; confirms disparities in large cohorts and leaves open questions on targeted interventions.
Meta-Analysis (n=1,268,664)
Does female sex reduce survival and favorable neurological outcomes in patients with out-of-hospital cardiac arrest compared to male sex?
Odds Ratio: 0.73 (95% CI 0.62–0.86)
Female patients with out-of-hospital cardiac arrest have significantly lower rates of survival to discharge and favorable neurological outcomes compared to males, potentially driven by differences in baseline characteristics and lower rates of in-hospital interventions.
Lei et al. (2020) conducted a meta-analysis in Out-of-hospital cardiac arrest (OHCA) (n=1,268,664). Female sex vs. Male sex was evaluated on Survival from OHCA to discharge (OR 0.73, 95% CI 0.62-0.86). Female sex was associated with a significantly lower chance of overall survival to hospital discharge after out-of-hospital cardiac arrest compared with male sex (OR 0.73).
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