Features of the Course of Metapneumoviral Infection in Adults

The objective: to determine the clinical features of metapneumovirus infection in adults and to determine the effect of coinfection on the severity of the course.Materials and methods. Bibliosemantic and analytical methods were used for this work. Recent scientific publications of such electronic databases as PubMed, Skopus, Cochrane have been analyzed.Results. The prevalence of metapneumovirus infection is 4–13%. Although most children are infected with HMPV by the age of 5, reinfection is possible throughout adulthood. HMPV was detected in 13% of hospitalized adults with acute respiratory disease inRochester,New York. Clinical manifestations of HMPV infection are diverse. Most common symptoms are bronchiolitis, pneumonia, exacerbation of bronchial asthma. The incidence of viral coinfection is from 6 to 23%.Conclusions. HMPV-infection has a mild course in healthy young people, but in the elderly, with concomitant pathology, has a more severe course and is characterized by higher mortality. Coinfection with other viruses or bacteria can worsen the patient’s symptoms and condition, but the severity of the disease does not seem to be affected.