hMPV replicates most efficiently in LLC-MK2 cells compared to Vero and HEp-2 cells.
LLC-MK2 may optimize hMPV propagation in vitro; leaves open validation for clinical diagnostics.
Human metapneumovirus (hMPV) is associated with acute respiratory tract disease especially in young children. Using a quantitative real-time TaqMan PCR, we analyzed the replication kinetics of hMPV in different cell lines. Our results indicate that hMPV replicates slightly more efficiently in LLC-MK2 than in Vero cells and poorly in HEp-2 cells.
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Deffrasnes et al. (2005) studied this question.
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