Barry H. Margolin, Byung Soo Kim, Kenneth J. Risko, The Ames Salmonella/Microsome Mutagenicity Assay: Issues of Inference and Validation, Journal of the American Statistical Association, Vol. 84, No. 407 (Sep., 1989), pp. 651-661
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Margolin et al. (1989) studied this question.
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