Postoperative Radiotherapy for Stage pT3 Carcinoma of the Prostate: Improved Local Control

No AccessJournal of UrologyClinical Urology: Original Article1 Jun 1996Postoperative Radiotherapy for Stage pT3 Carcinoma of the Prostate: Improved Local Control Isabel Syndikus, Tom Pickles, Edmund Kostashuk, and Lorne D. Sullivan Isabel SyndikusIsabel Syndikus , Tom PicklesTom Pickles , Edmund KostashukEdmund Kostashuk , and Lorne D. SullivanLorne D. Sullivan View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66069-5AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We determined whether radiotherapy after radical prostatectomy leads to improved results in patients with stage pT3 carcinoma of the prostate. Materials and Methods: In a prospective nonrandomized study of 203 patients with clinical stage T2 prostate cancer treated with radical prostatectomy 88 underwent surgery alone, 89 received early postoperative radiotherapy generally because of pathological stage T3 disease and 26 received delayed radiotherapy for local recurrence. The disease was stage pT3N0/X in 135 patients. Results: For patients with pathological stage T3 cancer actuarial local recurrence rates were significantly decreased in the early postoperative radiotherapy group compared to the surgery only group (p = 0.005), while actuarial metastatic rates (p = 0.6) and cause specific survival rates (p = 0.04) were not significantly different. Multivariate analysis for all patients in both groups identified adverse features of increased postoperative prostate specific antigen levels, seminal vesicle involvement, lack of postoperative radiotherapy and positive lymph nodes. Late toxicity was severe (Radiation Therapy Oncology Group grade 3 or 4) in 13 surgery only and 17 early postoperative radiotherapy group patients. Of those who were potent postoperatively the incidence of impotence in the early postoperative radiotherapy group was 89 percent compared to 59 percent in the surgery only group (p = 0.003). For patients treated with delayed radiation for clinical local recurrence the actuarial local control rate was 54 percent after 10 years. Conclusions: Local radiotherapy appears to improve local control of stage pT3 cancer but has no impact on overall survival. References 1 : Influence of wide excision of the neurovascular bundle(s) on prognosis in men with clinically localized prostate cancer with established capsular penetration. J. Urol.1993; 150: 142. Link, Google Scholar 2 : Residual disease after radical surgery or radiation therapy for prostate cancer. Clinical significance and therapeutic implication. Cancer, suppl.1993; 71: 959. 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Google Scholar From the British Columbia Cancer Agency and Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada.© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byGROSSFELD G, TIGRANI V, NUDELL D, ROACH M, WEINBERG V, PRESTI J, SMALL E and CARROLL P (2018) MANAGEMENT OF A POSITIVE SURGICAL MARGIN AFTER RADICAL PROSTATECTOMY: DECISION ANALYSISJournal of Urology, VOL. 164, NO. 1, (93-100), Online publication date: 1-Jul-2000.LEIBOVICH B, ENGEN D, PATTERSON D, PISANSKY T, ALEXANDER E, BLUTE M, BERGSTRALH E and ZINCKE H (2018) BENEFIT OF ADJUVANT RADIATION THERAPY FOR LOCALIZED PROSTATE CANCER WITH A POSITIVE SURGICAL MARGINJournal of Urology, VOL. 163, NO. 4, (1178-1182), Online publication date: 1-Apr-2000.ROGERS R, GROSSFELD G, ROACH M, SHINOHARA K, PRESTI J and CARROLL P (2018) RADIATION THERAPY FOR THE MANAGEMENT OF BIOPSY PROVED LOCAL RECURRENCE AFTER RADICAL PROSTATECTOMYJournal of Urology, VOL. 160, NO. 5, (1748-1753), Online publication date: 1-Nov-1998.WIEDER J and SOLOWAY M (2018) INCIDENCE, ETIOLOGY, LOCATION, PREVENTION AND TREATMENT OF POSITIVE SURGICAL MARGINS AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCERJournal of Urology, VOL. 160, NO. 2, (299-315), Online publication date: 1-Aug-1998.Van Cangh P, Richard F, Lorge F, Castille Y, Moxhon A, Opsomer R, De Visscher L, Wese F and Scaillet P (2018) ADJUVANT RADIATION THERAPY DOES NOT CAUSE URINARY INCONTINENCE AFTER RADICAL PROSTATECTOMY: RESULTS OF A PROSPECTIVE RANDOMIZED STUDYJournal of Urology, VOL. 159, NO. 1, (164-166), Online publication date: 1-Jan-1998. Volume 155Issue 6June 1996Page: 1983-1986 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.MetricsAuthor Information Isabel Syndikus More articles by this author Tom Pickles More articles by this author Edmund Kostashuk More articles by this author Lorne D. Sullivan More articles by this author Expand All Advertisement PDF downloadLoading ...