Why the study?
The role of the oral prostacyclin analog beraprost sodium in ventilator weaning failure has not been widely described.
Does oral beraprost induce ventilator weaning failure in patients with severe pre-existing ventilation-perfusion mismatch?
Population
One 90-year-old man with extensive atelectasis and critical limb ischemia
Comparison
Oral beraprost administration, discontinuation, and reintroduction
Design
Case report
Key result
Oral beraprost induced recurrent hypoxemia and tachypnea in a patient with extensive atelectasis, leading to refractory ventilator weaning failure that resolved upon drug discontinuation.
Authors
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Suggests beraprost may contribute to weaning failure in atelectasis; single-case observation leaves causality and generalizability open.
Case Report (n=1)
Does oral beraprost induce ventilator weaning failure in patients with severe pre-existing ventilation-perfusion mismatch?
Oral beraprost may contribute to recurrent hypoxemia and tachypnea in patients with severe pre-existing ventilation-perfusion mismatch, leading to ventilator weaning failure.
Obayashi et al. (2026) conducted a case report in Ventilator weaning failure (n=1). Beraprost sodium was evaluated on Resolution of ventilator weaning failure upon dechallenge. Oral beraprost induced recurrent hypoxemia and tachypnea in a patient with extensive atelectasis, leading to refractory ventilator weaning failure that resolved upon drug discontinuation.