Toward the precision use of Chinese PARP inhibitors in ovarian cancer: clinical progress, resistance mechanisms, and future perspectives

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The aim is to explore the current clinical progress of PARP inhibitors for ovarian cancer and understand resistance mechanisms.
Review of global incidence and mortality rates of ovarian cancer.
Analysis of clinical studies on PARP inhibitors in ovarian cancer treatment.
Discussion of resistance mechanisms and potential future research directions.
Ovarian cancer incidence and mortality continue to rise, particularly in China.
Clinical use of PARP inhibitors shows promise but faces challenges due to resistance mechanisms.
Future perspectives suggest a need for personalized treatment strategies in ovarian cancer management.

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This review discusses clinical progress and resistance mechanisms in ovarian cancer, suggesting future directions for precision therapy.

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Yu et al. (2026) studied this question.

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