Here we present a strategy to stabilize DNA triplexes by the attachment of perfluorinated tails to the 3′ and/or 5′ end of oligodeoxyribonucleotides. The tails preferentially associate with one another via the “fluorous effect” without compromising sequence selectivity. The most stable complex resulted in a dramatic 14 °C increase in melting temperature at neutral pH. This orthogonal recognition approach broadens the applications of triplex DNA in diagnostics, therapy, and DNA nanotechnology.
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Taladriz‐Sender et al. (2026) studied this question.
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