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June 4, 20260 citations

Fibroblast Activation Protein-Targeted Radiopharmaceutical Therapy Using 177Lu-, 90Y-, and 225Ac-Labeled 3BP-3940: First Experience in 21 Different Advanced Malignancies.

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RBRichard P. BaumTZTianzhi ZhaoVJVivianne Jakobsson

Key Points

  • To evaluate the effectiveness and safety of fibroblast activation protein-targeted radiopharmaceutical therapy (3BP-3940) in different advanced malignancies.
  • Conducted treatment in 21 different advanced malignancies including metastatic adenocarcinomas and sarcomas.
  • Monitored biodistribution, tumor uptake, and patient tolerance over the course of treatment.
  • Evaluated survival benefits and response rates after treatment.
  • 3BP-3940 demonstrated significant tumor uptake with high tumor-to-background ratios.
  • No serious adverse effects were noted, indicating good tolerability.
  • Preliminary survival benefits observed suggest the potential effectiveness of this therapy.

Abstract

Ac alone or as tandem treatment for patients with end-stage cancer. Treatments were relatively well tolerated without serious adverse effects. 3BP-3940 FRT demonstrated favorable biodistribution (exceptionally very low renal accumulation), significant tumor uptake, and long retention with very high tumor-to-background ratios, demonstrating objective responses in advanced, aggressive, and heavily pretreated metastatic adenocarcinomas and sarcomas. The observed survival benefit appears to be highly promising. Further prospective randomized analysis in a larger cohort with longer follow-up is warranted.

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Cite This Study

Baum et al. (2026) studied this question.

synapsesocial.com/papers/6a2115f6d499ed480b16eef8https://doi.org/10.2967/jnumed.125.271129
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