Significance of Her2neu, p53, and Ki67 expression in invasive urothelial carcinoma

Objectives: The main objective of the study is to correlate immunohistochemistry (IHC) expression of Her2neu, p53, and Ki67 with clinicopathological parameters in invasive urothelial carcinoma (UC) cases. Materials and Methods: Sixty cases of invasive UC were included in the study. IHC for Her2neu, p53, and Ki67 was performed in all these cases and correlated with clinicopathological parameters such as age, sex, smoking history, grade, and stage of tumor. Statistical analysis: Performed using SPSS software version 11.5 (SPSS, Chicago, IL, USA), and the Chi-square test was used to compare the variables. A p <0.05 was considered statistically significant. Results: The mean age was 61 years, with the majority of patients being male (96.6%). Half of the patients were smokers, and the majority of cases were high-grade UC (73.3%). A statistically significant correlation was noted between Her2neu, p53, and Ki67 expression with grade and stage of tumor ( p <0.05). There was no significant correlation between these IHC expressions and age, sex, and smoking history of patients. Furthermore, it was noted that a statistically significant correlation was also noted between positive IHC expression of Ki67 with Her2neu and p53. Conclusions: The expression of Her2neu, p53, and Ki67 is more prevalent in invasive UCs of higher grade and stage. Their expression in these cases can suggest a possible role in the clinical prognostication of these cases.