Visible-Light-Induced and Diastereoselective Synthesis of Fluorinated Tetrahydrofuran Derivatives

Key Points

• The research aims to address the challenges in synthesizing complex molecules with multiple stereocenters through new methods.
• Utilized a visible-light-driven, three-component cascade reaction.
• Focused on regioselectivity and diastereoselectivity in the synthesis process.
• Investigated the efficiency of the radical cascade method.
• Achieved efficient synthesis of fluorinated tetrahydrofuran derivatives with high yield and selectivity.
• Successfully demonstrated the construction of three contiguous stereocenters in a single reaction.
• Radical cascade process showed significant improvement over conventional methods.