What question did this study set out to answer?

This review aims to explore factors influencing the progression of axSpA to radiographic stages, focusing on risk stratification.

Progression to Radiographic Axial Spondyloarthritis: A Narrative Review on Timeline and Novel Prediction Factors

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This review aims to explore factors influencing the progression of axSpA to radiographic stages, focusing on risk stratification.
Narrative review of existing literature on axSpA progression and predictive biomarkers.
Analysis of disease progression based on clinical studies and biomarkers associated with structural damage.
Discussion on the role of specific biomarkers like HLA-B27 and fetuin-A in patient classification.
Structural changes in axSpA typically progress over a mean duration of 2.4 years.
Biomarkers such as HLA-B27 and C-reactive protein are linked to risk categorization for radiographic progression.
Novel biomarkers like Dickkopf-1 and adipokines show promise in predicting structural damage and guiding treatment.

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Narrative review addresses progression timeline and prediction factors in axial spondyloarthritis, suggesting implications for risk stratification.

Murgu et al. (2026) studied this question.

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Narrative review addresses progression timeline and prediction factors in axial spondyloarthritis, suggesting implications for risk stratification.