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June 4, 2026npj Antimicrobials and ResistanceOpen Access

Metagenomic profiling reveals shared resistome signatures between humans and pigs in Vietnamese smallholder farms

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Authors

LLLe Thi Kieu LinhTMTruong Nhat MyNTNhat Thi Tran

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Overview

Randomized trial demonstrates shared antimicrobial resistance genes in humans and pigs, highlighting the need for One Health strategies.

Key Points

  • This research aims to explore the extent of antimicrobial resistance gene exchange between humans and pigs.
  • Shotgun metagenomic sequencing of paired faecal samples from pigs and their caretakers across 50 small-scale farms.
  • Analysis of antimicrobial resistance gene types and abundances in both hosts.
  • Identification of closely related Escherichia coli strains in humans and pigs.
  • 10,270 antimicrobial resistance genes identified, with 550 unique types, including mcr, bla OXA-58, and optrA.
  • 52% of antimicrobial resistance genes were shared between pigs and caretakers, indicating significant microbial exchange.
  • Pigs had a higher total abundance of antimicrobial resistance, while workers exhibited richer resistomes.

Cite This Study

Linh et al. (2026) studied this question.

synapsesocial.com/papers/6a211689d499ed480b16f7e6https://doi.org/10.1038/s44259-026-00223-6
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