Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study

Andrea Quattrone; Andrea Quattrone; Maria Giovanna Bianco; Basilio Vescio; Ilaria Chimento; Alisea Sacilotti; Cesare Oliveti; Pier Paolo Arcuri; C Stanà; Emanuele Tinelli; Umberto Sabatini; Valtteri Kaasinen; N Franzmeier; Leonidas Stefanis; Georgios Velonakis; Adam Boxer; Vasilios C. Constantinides; G Höglinger; Aldo Quattrone; Aldo Quattrone; on behalf of the PASSPORT Study Group; the AL-108-231 Investigators; the AL-108-231 Investigators; the DescribePSP group; Ikuko Aiba; Angelo Antonini; Diana Apetauerova; Jean-Philippe Azulay; Ernest Balaguer Martinez; Jee Bang; Paolo Barone; Matthew Barrett; Danny Bega; Daniela Berg; Koldo Berganzo Corrales; Yvette Bordelon; Adam L Boxer; Moritz Brandt; Norbert Brueggemann; Giovanni Castelnovo; Roberto Ceravolo; Rosalind Chuang; Sun Ju Chung; Alistair Church; Jean-Christophe Corvol; Paola Cudia; Marian Dale; Luc Defebvre; Sophie Drapier; Erika Driver‐Dunckley; Georg Ebersbach; Karla M. Eggert; Aaron Ellenbogen; Alexandre Eusébio; Andrew Evans; Natalia Fedorova; Elizabeth Finger; Alexandra Foubert-Samier; Boyd Ghosh; Lawrence I. Golbe; Francisco Grandas Pérez; Murray Grossman; Deborah Hall; Kyoko Hamada; Kazuko Hasegawa; Guenter Hoeglinger; Lawrence Honig; David Houghton; Xuemei Huang; Stuart Isaacson; Seong-Beom Koh; J. Kulisevsky Bojarski; Anthony E. Lang; Peter Leigh; Irene Litvan; Juan Jose Lopez Lozano; J L López Sendón-Moreno; Albert Christian Ludolph; Ma Rosario Luquin Piudo; Irene Martinez Torres; Nikolaus McFarland; Wassilios Meissner; Tiago Mestre; Pablo Mir Rivera; Eric Molho; Britt Mollenhauer; Huw R. Morris; Miho Murata; Tomokazu Obi; Fabienne Ory Magne; Padraig O’Suilleabhain; Rajesh Pahwa; Alexander Pantelyat; Nicola Pavese; Д. В. Похабов; Johannes Prudlo; Federico Rodriguez-Porcel; James Rowe; Joseph Savitt; Alfons Schnitzler

doi:10.1148/radiol.251394

June 1, 2026RadiologyOpen Access

Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study

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Key Points

The study aims to evaluate the effectiveness of MRI markers in classifying progressive supranuclear palsy (PSP) compared to other neurodegenerative disorders.
Conducted a multicohort international study with large participant numbers.
Utilized planimetric and linear MRI markers for analysis.
Registration in clinical trials NCT03068468, NCT01110720, NCT01049399, NCT01804452.
The DMPI and midbrain area markers showed high effectiveness for differentiating PSP from other neurodegenerative parkinsonisms (AUC, 0.94 [95% CI: 0.86, 1.00]).

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Implication

Demonstrates effective MRI markers for distinguishing PSP in diverse populations, indicating potential diagnostic advancements.

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Quattrone et al. (2026) studied this question.

synapsesocial.com/papers/6a2116cfd499ed480b16fb3d https://doi.org/10.1148/radiol.251394

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Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Planimetric and Linear MRI Markers for Progressive Supranuclear Palsy Classification: A Large Multicohort International Study

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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