Electromagnetic Antagonism of D2 Dopamine Receptors: A Theoretical Framework for Non-Invasive Neuromodulation

This paper proposes a speculative theoretical framework for frequency-selective neuromodulation usingexternally generated electromagnetic fields. The proposed architecture explores whether dopaminergicreceptor dynamics may eventually be perturbed through resonance-oriented electromagnetic couplingrather than conventional ligand-based antagonism. Drawing from terahertz spectroscopy, receptorconformational energetics, quantum biology, and electromagnetic tissue propagation models, theframework introduces a conceptual architecture referred to as Electromagnetic Neuro-Modulation (ENMR).The work is intentionally positioned as a hypothesis-driven interdisciplinary research direction rather thanan experimentally validated biomedical technique. Key physical constraints including terahertz attenuation,thermal decoherence, spatial targeting limitations, and receptor-scale uncertainty are discussed. Potentialcomputational and nanophotonic research directions are also outlined.