Syntheses and CD studies of optically active substituted 1,3,4,5‐tetrahydro‐2H‐1,5‐benzodiazepin‐2‐ones

A route to optically active variously substituted 4‐methyl‐ and 4‐methyl‐7‐substituted 1,3,4,5‐tetrahydro‐2 H ‐1,5‐benzo‐diazepin‐2‐ones as analogues of commercially available Lofendazam (7‐chloro‐5‐phenyl‐1,3,4,5‐tetrahydro‐2 H ‐1,5‐benzodiazepin‐2‐one, 1 ) was developed. Fortyone variously substituted optically active compounds having the same configuration were prepared and the UV and CD spectra of the parent compounds bearing no additional substitution in the benzene ring are discussed.