Development and Evaluation of Colon Targeted Drug Delivery System of Metronidazole

ABSTRACTColon targeted drug delivery systems have gained considerable attention due to their ability todeliver drugs directly to the colon and reduce systemic side effects. The present study focuseson the formulation and evaluation of colon targeted tablets of Metronidazole using suitablepolymers. Tablets were prepared using direct compression method with varying concentrationsof HPMC K4M and xanthan gum. Preformulation studies including drug identification,solubility analysis, and compatibility studies were performed. The prepared formulations wereevaluated for pre-compression parameters such as angle of repose, bulk density, tapped density,Carr's index, and Hausner ratio. Post-compression parameters including hardness, thickness,friability, weight variation, and drug content were evaluated. In-vitro drug release study wasperformed using dissolution apparatus in simulated gastrointestinal conditions. Stability studieswere conducted according to ICH guidelines. The optimized formulation showed controlleddrug release and minimal release in gastric medium, confirming colon targeted delivery ofMetronidazole.