Network Pharmacology and Experimental Evaluation of the Therapeutic Potential of Hygrophila Schulli (Kokilaksha) Seeds in the Treatment of Hyperlipidemia

Kannur Dayanand M, Ingale Suvarna, Mistry Falguni C, Naik Anajli S, Pawar Shubham, Joshi Anagha M, Khandelwal Kishanchandra R

doi:10.5281/zenodo.20508264

June 2, 2026Open Access

Network Pharmacology and Experimental Evaluation of the Therapeutic Potential of Hygrophila Schulli (Kokilaksha) Seeds in the Treatment of Hyperlipidemia

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Key Points

The aim is to evaluate the antihyperlipidemic potential of Hygrophila schulli seeds and identify relevant molecular targets.
Utilized network pharmacology using databases like PubChem and Cytoscape to model interactions and pathways.
Induced hyperlipidemia in animals using a high-fat diet and administered seed extracts while measuring lipid profiles.
Conducted molecular docking simulations to assess the binding interactions of bioactive compounds with lipid metabolism regulatory proteins.
Triglyceride and cholesterol levels significantly decreased in hyperlipidemic animals after extract administration, p<0.05.
HDL levels significantly increased with the hexane extract, indicating improved lipid profiles, p<0.01.
Hepatic lipid buildup was effectively inhibited by both extracts, showcasing their potential in treating hyperlipidemia.

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Implication

Evaluates antihyperlipidemic effects of Hygrophila schulli seeds, suggesting natural therapy for metabolic diseases.

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Cite This Study

Kannur Dayanand M, Ingale Suvarna, Mistry Falguni C, Naik Anajli S, Pawar Shubham, Joshi Anagha M, Khandelwal Kishanchandra R (2026) studied this question.

synapsesocial.com/papers/6a2117a4d499ed480b1706c5 https://doi.org/10.5281/zenodo.20508264

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Network Pharmacology and Experimental Evaluation of the Therapeutic Potential of Hygrophila Schulli (Kokilaksha) Seeds in the Treatment of Hyperlipidemia

Key Points

No abstract yet

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Implication

Discussion

Cite This Study

Network Pharmacology and Experimental Evaluation of the Therapeutic Potential of Hygrophila Schulli (Kokilaksha) Seeds in the Treatment of Hyperlipidemia

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

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