Evaluates N-acetylcysteine's impact on fibrosis in fibroblasts from recessive dystrophic epidermolysis bullosa, suggesting new therapeutic options.
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disease caused by pathogenic biallelic variants in COL7A1, resulting in dermal-epidermal fragility and chronic, non-healing wounds1. We investigated the contribution of fibroblast senescence to RDEB wound pathology and evaluated whether NAC can modulate this process.
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Catalán et al. (2026) studied this question.
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