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June 4, 2026NutrientsOpen Access

Fungal β-1,3-glucans: Cell Wall Constituents That Promote Gut Health Through Innate Immune Modulation

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Authors

FSFnu SamikshaDSDrishtant SinghSHSudi Shatha Harbool

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Overview

Randomized trial demonstrates gut health benefits of fungal β-1,3-glucans through immune modulation, suggesting therapeutic potential.

Key Points

  • This research investigates how fungal β-1,3-glucans support gut health by modulating immune responses.
  • Examined the immunomodulatory effects of β-1,3-glucans via receptor binding and immune response activation.
  • Studied the role of dietary β-1,3-glucans in gut microbiota composition and function as prebiotic fibers.
  • Evaluated therapeutic implications for diseases like inflammatory bowel disease and cancer.
  • Binding of β-1,3-glucans triggers cytokine production, enhancing innate immunity.
  • Increased short-chain fatty acid production was observed, improving gut microbiota balance.
  • β-1,3-glucans showed effectiveness in enhancing anti-tumor immunity and improving cancer treatment responses.

Cite This Study

Samiksha et al. (2026) studied this question.

synapsesocial.com/papers/6a2117bfd499ed480b170876https://doi.org/10.3390/nu18111794
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