Demonstrates the effectiveness of split RNA polymerases in biosensor development, suggesting potential in genetic engineering.
A proximity dependent split T7 RNAP (RNA polymerase) sensor using continuous molecular evolution is described. The versatility of the platform is described by creating robust light and small molecule-responsive genetic sensors. The activity-responsive RNAP platform dramatically simplifies and expands genetic circuit creation, and opens new opportunities in protein engineering, synthetic biology, and bioengineering.
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Dickinson et al. (2017) studied this question.
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