Angiotensin II prevents the metabolic but not the transdifferentiating effect of EGF on vascular smooth muscle cells from human female donors

Key Points

• This research investigates how angiotensin II affects the metabolic and transdifferentiating effects of EGF on vascular smooth muscle cells.
• Isolated vascular smooth muscle cells from human female donors were treated with angiotensin II and EGF.
• Assessments of metabolic and transdifferentiating effects were conducted.
• Comparative analyses were performed to evaluate outcomes.
• Angiotensin II effectively prevented the metabolic effects induced by EGF in vascular smooth muscle cells.
• No significant effect of angiotensin II was observed on EGF's ability to induce transdifferentiation.
• Findings suggest distinct pathways for metabolic changes and transdifferentiation in vascular smooth muscle cells.