Key result
Idiopathic cardiomyopathy subtypes had varying sudden death rates, comprising 22% of deaths in congestive/dilated, 54% in hypertrophic nonobstructive, and 45% in hypertrophic obstructive types.
Observational (n=540)
Yes
Sudden death constitutes a major proportion of mortality in idiopathic cardiomyopathy, especially in hypertrophic variants where it is frequently associated with exercise.
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Subtype differences in sudden death proportion support cautious risk stratification by cardiomyopathy type; leaves open need for prospective validation of targeted prevention.
The incidence of sudden death in idiopathic cardiomyopathy was analyzed based on a multi-center study in Japan, and possible prevention was discussed. Among 540 cases reported from 15 institutions, sudden death was most frequent in congestive or dilated type (19 cases, 22% of 87 deaths) and the ratio of sudden death to all deaths was high in the hypertrophic nonobstructive type (7 cases, 54% of 13 deaths) or the hypertrophic obstructive type (5 cases, 45% of 11 deaths). In the latter 2 types, the occurrence of sudden death seemed to be more related to exercise than in the congestive type. In the analysis of 4 sudden deaths among patients in congestive type, sudden death occurred in relatively asymptomatic patients after recovery from acute congestive heart failure. For the effective prevention, detection of undiagnosed patients by electrocardiographic screening, education of patients to avoid unprepared exercise, evaluation of physical tolerance by exercise testing and need for official registration of victims were discussed.
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Sakurai et al. (1983) conducted an observational in Idiopathic cardiomyopathy (n=540). Idiopathic cardiomyopathy subtypes was evaluated on Sudden death. Idiopathic cardiomyopathy subtypes had varying sudden death rates, comprising 22% of deaths in congestive/dilated, 54% in hypertrophic nonobstructive, and 45% in hypertrophic obstructive types.
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