Enantiodivergent Formal Synthesis of (+)- and (−)-Cyclophellitol from d-Xylose Based on the Latent Symmetry Concept

Formal synthesis of (+)- and (-)-cyclophellitol from d-xylose has been accomplished through utilization of the latent plane of chirality present in the starting carbohydrate. The synthetic pathway is suitable for preparation and biological evaluation of cyclophellitol analogues in both enantiomeric series.