A novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics was developed to identify the contribution of electrical and mechanical alterations to calcium and force regulation.
A novel publicly available human electromechanical cardiomyocyte model helps uncover arrhythmogenic mechanisms by differentiating the effects of beta-adrenergic stimulation and stretch.
This work identifies the contribution of electrical and mechanical alterations to regulation of calcium and force under exercise-like conditions using a novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics. By better understanding their individual and combined effects, this can uncover arrhythmogenic mechanisms in exercise-like situations. This publicly available model is a crucial step toward understanding the complex interplay between cardiac electrophysiology and mechanics to improve arrhythmia risk prediction and treatment.
Lyon et al. (Fri,) conducted a other in Arrhythmia. Electromechanical cardiomyocyte model was evaluated on Contribution of electrical and mechanical alterations to regulation of calcium and force. A novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics was developed to identify the contribution of electrical and mechanical alterations to calcium and force regulation.