Key result
A novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics was developed to identify the contribution of electrical and mechanical alterations to calcium and force regulation.
Why the study?
Understanding the individual and combined effects of electrical and mechanical alterations on calcium and force regulation can uncover arrhythmogenic mechanisms under exercise-like conditions.
A novel publicly available human electromechanical cardiomyocyte model helps uncover arrhythmogenic mechanisms by differentiating the effects of beta-adrenergic stimulation and stretch.
New model enables in silico dissection of arrhythmogenic triggers; leaves open clinical translation pending validation.
This work identifies the contribution of electrical and mechanical alterations to regulation of calcium and force under exercise-like conditions using a novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics. By better understanding their individual and combined effects, this can uncover arrhythmogenic mechanisms in exercise-like situations. This publicly available model is a crucial step toward understanding the complex interplay between cardiac electrophysiology and mechanics to improve arrhythmia risk prediction and treatment.
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Lyon et al. (2020) studied Arrhythmia. Electromechanical cardiomyocyte model was evaluated on Contribution of electrical and mechanical alterations to regulation of calcium and force. A novel human electromechanical model integrating ventricular electrophysiology and sarcomere mechanics was developed to identify the contribution of electrical and mechanical alterations to calcium and force regulation.
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