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The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug – drug interactions are likely to occur through either mechanism. Keywords: protein binding, CYP isoforms, Hepatocytes, omeprazole, glucuronidation
Kneip et al. (Tue,) studied this question.