Chronic lung disease, with or without pulmonary hypertension, was associated with a significant decrease in early tricuspid flow propagation velocity compared to healthy controls (p<0.0001).
Observational (n=365)
Does chronic lung disease with or without pulmonary hypertension affect right ventricular diastolic function compared to healthy individuals?
Patients with chronic lung disease exhibit impaired right ventricular diastolic function and increased right heart size even before the development of pulmonary hypertension.
valor p: p=<0.0001
AIM: To investigate the indicators of filling of the right ventricle (RV) in patients with chronic lung diseases with and without pulmonary hypertension (PH) compared to healthy individuals. SUBJECTS AND METHODS: 365 people (198 men); mean age 64.6±8.0 years) were examined and divided into a group of patients with respiratory pathology without and with PH (n=124 and n=138, respectively) and a comparison group that included individuals without cardiovascular and respiratory diseases (n=103). All underwent echocardiography with examination of RV filling flows (Et, At, Et/At), data of the spectral tissue Doppler imaging of the fibrous ring of the tricuspid valve (e't, a't, e't/a't), and early tricuspid flow propagation velocity (ETFPV). RESULTS: All the groups were found to have an e't/a't decrease to 0.75 (0.63-0.90) - 0.8 (0.63-1.0; p=0.26). The groups showed no noticeable differences in indicators, such as Еt/Аt, e't/a't, and Еt/e't ratios, although the increased size of the right heart was noted in patients without PH along with the ETFPV decrease from 33.5 (28-39) to 31.5 (24.5-36) cm/sec, which continued to substantially decline to 27.1 (24-35) cm/sec in patients with PH (p<0.0001). CONCLUSION: Patients with chronic lung disease even without the development of PH exhibited a decreased ETFPV along with the increased size of the right heart. Another indicator of RV diastolic function is a tricuspid valve annular velocity ratio in early and late diastole; the e't/a't ratio was not considerably different in the groups, although its decline was observed in all the groups probably due to age-related changes. Thus, RV diastolic function should be comprehensively evaluated in patients with lung disease regardless of the presence of PH.
Сумин et al. (Wed,) conducted a observational in Chronic lung diseases with and without pulmonary hypertension (n=365). Chronic lung disease with or without pulmonary hypertension vs. Healthy individuals without cardiovascular and respiratory diseases was evaluated on Early tricuspid flow propagation velocity (ETFPV) (p=<0.0001). Chronic lung disease, with or without pulmonary hypertension, was associated with a significant decrease in early tricuspid flow propagation velocity compared to healthy controls (p<0.0001).