Population
Muscle cells and nonmuscle cells transfected with MyoD, myogenin, or myf5 expression vectors
Comparison
Mutation of MyoD binding sites in the myosin… vs Wild-type (unmutated) MLC gene enhancer
Design
Preclinical
Authors
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Cautions against extrapolating animal enhancer data to human myopathies; leaves open cooperative MyoD mechanisms in cardiac models.
A protein-DNA complex involving at least two MyoD binding sites (A and C or B and C) is required to activate the MLC1/3 locus during myogenesis.
Wentworth et al. (1991) studied this question.
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