Answers are grounded in this paper and cite their sources.
Experimental analysis reveals how geometric constraints affect metal ion binding in disordered protein domains, indicating potential misfolding risks.
induces a partially folded structure. These results highlight the importance of geometric constraints imposed by protein structure in determining metal ion selectivity, yielding insights into how off-target ion binding may result in protein misfolding and malfunction.
No takes yet. Share an insight, caveat, or question.
Gudinas et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: